Mutual Support, Debates & Great Ideas for Improving the OH Participatory Platform

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Source: {"body":{"en":"<p><strong>Why oligonucleotide drugs?</strong></p>\n<p>Synthetic oligonucleotides are the key factor in almost all molecular biological methodologies. They are used in PCR, reverse transcription, sequencing, gene editing, synthetic biology, cloning, single nucleotide polymorphism analysis, microarray, electrophoretic mobility analysis, and small RNA studies. Most of these technological advances require synthesized oligonucleotides of high quality, completeness, and purity.</p>\n<p>The currently marketed oligonucleotide drugs are mainly chemically modified to improve the metabolic stability of nucleotide structure and reduce adverse reactions, for instance, the modification of phosphodiester bonds, ribose, nucleotide bases, or ribose-phosphate backbones. Compared with the traditional drug development model, the new generation oligonucleotide drugs have obvious advantages. Conventional small-molecule drug development requires a great deal of screening and optimization process while oligonucleotide drug candidates can be quickly screened based on the primary gene sequence, and then high-specificity lead compounds can be designed. In addition, the unique function mechanism of nucleotide drugs allows them to modulate target activities that are not recognized by small molecules, thus providing a wider range of clinical applications.</p>\n<p><strong>Classifications and research focus</strong></p>\n<p><a href=\"https://www.bocsci.com/blog/fda-approved-oligonucleotide-drugs/\">Approved Antisense oligonucleotide drugs (ASO)</a>, small interfering ribonucleic acid (siRNA), ribozyme, deoxyribozyme, etc. are all concluded as nucleotide drugs. Oligonucleotides can regulate gene expression through a series of processes such as RNA interference, ribonuclease-mediated degradation, splicing regulation, non-coding RNA inhibition, gene activation, and programmed genome editing. ASO and siRNA are recognized as the most commonly used gene regulation tools, which are widely used and have been developed as gene therapy drugs.</p>\ngid://decidim-openheritage/Decidim::Hashtag/1/_bug"},"title":{"en":"FDA Approved Oligonucleotide Drugs"}}

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